Chronic cough Respiratory Cough
Conditions
Interventions
Naltrexone, 50 mg naltrexone tablet or placebo administered to volunteers
Sponsors
South Manchester University Hospital (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male 2. Aged 18 - 75 years old 3. Normal lung function 4. No current or past history of chronic cough or chronic respiratory illness 5. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches 6. No current or past history of psychiatric illness 7. No current history of reflux disease or post-nasal drip syndrome
Exclusion criteria
Exclusion criteria: 1. Age >75 years 2. Recent upper respiratory tract infection (10 pack year smoking history 7. A previous or current history of liver disease 8. Dependency on opioids 9. Current use of opiates 10. Known hypersensitivity to naltrexone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of naltrexone compared to placebo on maximal capsaicin-induced cough frequency | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed