Contrast induced nephropathy Urological and Genital Diseases Nephropathy
Conditions
Interventions
Treatment group:
Patients will be given 600 mg twice daily N-acetylcysteine the day before the angiogram, and 600 mg twice on the day of the angiogram with intravenous fluids. Samples of urine and b
Sponsors
Cambridge University Hospital NHS Trust (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Any patient undergoing peripheral angiography in the Cambridge Vascular Unit, Addenbrooke?s Hospital, Cambridge who consents to participation.
Exclusion criteria
Exclusion criteria: 1. Any patient undergoing peripheral angiography in Cambridge Vascular Unit 2. Any patient that does not consent to participation in the study 3. Any patient under the age of 18 years 4. Any patient with established renal failure on renal replacement therapy (dialysis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primarily we are looking for a reduction in the elevation in Albumin/Creatinine ratio and also of other markers of renal damage in urine (retinol binding protein), using the samples collected before the angiogram and first, second and third day post angiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| A reduction in the mortality and morbidity related to renal failure that may result secondary to contrast solution used in angiography; this 30-day mortality morbidity reduction will be measured on follow up in clinic normally four to six weeks post angiography. | — |
Countries
United Kingdom
Outcome results
None listed