Recurrent in-vitro fertilisation (IVF) failure Pregnancy and Childbirth In-vitro fertilisation
Conditions
Interventions
The trial participants are randomised to one of two regimens:
1. Out-patient hysteroscopy in the follicular phase (days 5 - 14) of the menstrual cycle where the IVF cycle is due to start, followed by
Sponsors
Guy's and St Thomas' NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women undergoing an IVF (with or without intracytoplasmic sperm injection) treatment cycle who have had between 2 - 4 failed previous fresh IVF attempts ending in an embryo transfer 2. Aged 36 years or less 3. Willing and able to give informed consent Women who have had a previous hysteroscopy will be included.
Exclusion criteria
Exclusion criteria: 1. Women who had less than 2 or more than 4 failed fresh IVF attempts ending in an embryo transfer 2. Women aged more than 36 years (i.e. women aged 37 years or more) 3. Presence of submucous or intramural uterine fibroids distorting the uterine cavity or untreated tubal hydrosalpinges
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth event per cycle started, measured after 9 months of embryo transfer. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Embryo implantation rate 2. Pregnancy rate per IVF cycle started 3. Clinical pregnancy rate per IVF cycle started 4. Miscarriage rate per pregnancy achieved Measured 2 and 4 weeks after embryo transfer. | — |
Countries
United Kingdom
Outcome results
None listed