Neural correlates of response to COGnitive behaviour therapy in SCHIZophrenia: a functional magnetic resonance imaging investigation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35852420

Enrollment

100

Registered

2005-07-22

Start date

2002-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia Mental and Behavioural Disorders Schizophrenia

Interventions

Functional Magnetic Resonance Imaging (MRI) will be applied to investigate brain functions of 60 patients with schizophrenia, 30 of whom will undergo cognitive behaviour therapy. All patients will be

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a diagnosis of schizophrenia: 1. Who have shown partial or complete resistance to typical or atypical drug therapy 2. Are right handed 3. Have no history of neurological conditions or head injury 4. Can tolerate scanning 5. Can provide written consent

Exclusion criteria

Exclusion criteria: Evidence of primary drug or alcohol abuse or consumption of alcohol or street drugs within 24 hours of scheduled testing.

Design outcomes

Primary

Measure	Time frame
1. Blood-oxygenation-level-dependent response in cortical and sub-cortical regions 2. Symptom scores	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026