Preterm delivery Pregnancy and Childbirth Preterm delivery
Conditions
Interventions
Vaginal progesterone, 90 mg daily for ten weeks from 24 weeks gestation versus placebo
Sponsors
Greater Glasgow Health Board (North Glasgow University Hospitals Division) and the University of Glasgow (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women with twin pregnancy 2. Gestation established by scan before 20 weeks gestation 3. Known chorionicity
Exclusion criteria
Exclusion criteria: 1. Known signficiant structural or chromosomal fetal abnormality 2. Contraindications to progesterone 3. Planned cervical suture 4. Planned elective delivery before 34 weeks gestation 5. Intervention for twin to twin transfusion before 22 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of women in each group delivering before 34 weeks gestation | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy duration, maternal complication rates, neonatal complication rates, maternal side effects, acceptability of treatment, subject perception of alternatives, perinatal mortality, perinatal morbidity | — |
Countries
United Kingdom
Outcome results
None listed