A feasibility study of real-time displays of brain activity as a treatment for symptoms in Huntington's disease

Evaluating the feasibility of real-time fMRI neurofeedback training as a treatment for cognitive symptoms in Huntington's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35734205

Enrollment

Registered

2020-01-28

Start date

2016-02-12

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Huntington's disease Nervous System Diseases Huntington disease

Interventions

The study tests real-time fMRI neurofeedback training (NFT). Participants are randomized into four groups, two treatment groups, one receiving neurofeedback derived from the activity

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. > 18 years old 2. Pre-symptomatic gene-carriers, i.e. they will carry the HD gene, but will not have been clinically diagnosed (UHDRS diagnostic score of 4 or less) at the time of enrolment, OR 3. Early-stage 1 HD patients, i.e. patients with Total Functional Capacity (TFC) score between 11-13

Exclusion criteria

Exclusion criteria: Cannot be scanned in the MRI scanner

Design outcomes

Primary

Measure	Time frame
Participants’ ability to upregulate NFT target levels without feedback (near transfer) measured using fMRI at baseline and follow up (two months after training)	—

Secondary

Measure	Time frame
Measures of cognitive and psychomotor function at baseline and follow-up (two months after training): 1. Stroop word reading 2. Symbol Digit Modalities Task 3. Emotion Recognition 4. Circle Tracing 5. Paced and Speeded Tapping	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026