Correction of metabolic acidosis in continuous ambulatory peritoneal dialysis patients with borderline dialysis adequacy - effect on nutritional status, systemic inflammatory response and patient morbidity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35726272

Enrollment

Registered

2002-10-10

Start date

2000-12-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic acidosis Nutritional, Metabolic, Endocrine Acidosis

Interventions

Patients will be randomised to receive either: 1. Oral sodium bicarbonate 0.9 g three times a day (tds) 2. Placebo Patients were followed up for 12 months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. End-stage renal failure patients 2. Receiving Continuous Ambulatory Peritoneal Dialysis (CAPD) 3. Weekly Kt/V 1.6 to 1.9 4. Metabolic acidosis (plasma bicarbonate less than 24 mmol/l)

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Nutritional status 2. Total number of days in hospital admission during study period 3. All-cause mortality	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

Hong Kong

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026