Health effects of dietary supplementation of Sujiaonori (Ulva Profilera Muller) biomaterials on salivary adiponectin, cardiovascular risk parameters and skin health in healthy humans

Effects of daily intake of Sujiaonori (Ulva prolifera Muller) supplement on salivary adiponectin, cardiometabolic risk and skin health in healthy humans: a four-week placebo-controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35616776

Enrollment

Registered

2016-09-15

Start date

2016-02-26

Completion date

Unknown

Last updated

2023-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiometabolic risk markers and skin health Signs and Symptoms Cardiometabolic risk markers and skin health

Interventions

Forty male and female university students and staff who freely accepted to participate in this study are enrolled. At day 1 of the study (baseline), each participant is given an envelope on which his/

this envelope contains two survey questionnaires (described below), a pen and a number of supplement powder packs to be taken twice a day (3gr during breakfast and 3gr during dinner) for 28 days (each

or 3gr of placebo powder made of 70% corn starch mixed with 30% Japanese spinach to give it a green color). What supplement pack set each participant is given is allocated randomly. A

measurement of weight, height, blood pressure are performed 3 times and results are written at indicated locations on the survey sheet by the volunteer him/herself 1.1.2. Lifestyle-rel

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 20 years or older 2. University student or staff 3. No major health conditions (heart, liver, brain, kidney disease or diabetes) 4. Not taking any medication 5. Provision of written informed consent

Exclusion criteria

Exclusion criteria: 1. Known major health condition 2. Taking medication 3. Those who might not be able to attend on day 0 and 28 for saliva sampling and clinical evaluation 4. Personal or family history of sensitization or allergy to any algal food product

Design outcomes

Primary

Measure	Time frame
1. Salivary adiponectin and alpha-amylase levels, measured by ELISA at baseline and 28 days 2. Trans-epidermal water loss (TEWL), assessed via 3 measurements performed by a dermatologist (the best TEWL value was considered), by Cutometer dual MPA at baseline and 28 days	—

Secondary

Measure	Time frame
1. Blood pressure, measured using an electronic manometer (OMRON HEM-7321-E ) at baseline and 28 days 2. BMI is measured using height and weight measurements at baseline and 28 days 3. Current health status, assessed using a survey questionnaire designed for the purpose of this study and the ‘Dietary history assessment questionnaire (BDHQ)’ (a validated Japanese version of Food frequency questionnaire developed by the School of Public Health, Tokyo University, Japan) at baseline and 28 days	—

Measure

Time frame

1. Blood pressure, measured using an electronic manometer (OMRON HEM-7321-E ) at baseline and 28 days 2. BMI is measured using height and weight measurements at baseline and 28 days 3. Current health status, assessed using a survey questionnaire designed for the purpose of this study and the ‘Dietary history assessment questionnaire (BDHQ)’ (a validated Japanese version of Food frequency questionnaire developed by the School of Public Health, Tokyo University, Japan) at baseline and 28 days

—

Countries

Japan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026