Heavy alcohol use Mental and Behavioural Disorders Mental and behavioural disorders due to use of alcohol
Conditions
Sponsors
University of Manchester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Consumption of 21 or more units of alcohol per week but not meeting SCID criteria for dependence
Exclusion criteria
Exclusion criteria: 1. Participants must not meet criteria for alcohol dependence as per the Structured Clinical Interview for Depression (SCID) (as assessed at online screening and during baseline interview) 2. Positive drug/alcohol screens on testing visits. A minimum list of drugs that will be screened for include amphetamines, barbiturates, cocaine, opiates, cannabinoids and benzodiazepines. Positive results for cannabinoids will be allowed given the long half-life of cannabinoid metabolites. This exclusion criterion would exclude a subject from completing the study on that day only and not the study as a whole, at the discretion of the research team 3. High dosage use of regular psychoactive prescription medications such as those with antidepressant or anxiolytic properties. 4. History or presence of a neurological diagnosis (not limited to but including, for example, stroke, epilepsy, space occupying lesions, multiple sclerosis, Parkinson's disease, vascular dementia, transient ischemic attack) that may influence the outcome of any cognitive testing 5. Clinically significant head injury (e.g., requiring medical or surgical intervention) 6. Unwillingness or inability to follow the procedures outlined in the protocol 7. Significant current or past psychiatric history, including Major Depression, Generalised Anxiety Disorders, or anything that involves referral to secondary services and/or significant functional impairment 8. Neuroendocrine disorder, including impaired thyroid function and steroid use 9. Female participants who are, or may be, pregnant 10. Those with any contraindications for MRI scanning will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alcohol consumption measured using a 28-day Timeline Followback at baseline and one month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cognition measured using reaction times and errors on the Approach Avoidance and Visual Probe tasks at a single session 2. Blood-oxygen-level dependent (BOLD) activity assessed using MR techniques at a single session | — |
Countries
United Kingdom
Outcome results
None listed