Gastrointestinal Digestive System
Conditions
Interventions
There will be two groups A and B, to which the 20 participants will be randomly allocated. Group A will be MRI scanned using the chosen fluid to distend the colon. A few hours later group A will be MR
Sponsors
University of Leeds (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-30 2. Subjects will predominantly be sourced from Leeds Medical School allowing their exposure to clinical trials during their training.
Exclusion criteria
Exclusion criteria: 1. For anatomical reasons: history of GI disease or abdominal or pelvic surgery 2. For biochemical reasons: history of chronic cardiac or renal disease 3. Contraindications for the use of buscopan: allergy to buscopan 4. History of acute angle closure glaucoma, porphyria, myasthenia gravis and unstable cardiac disease 5. Ethical considerations: non consent for trial or unable to consent for trial 6. MRI considerations: any metal, cosmetic or therapeutic, will be an absolute contraindication, claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare patient tolerance of the use of fluid to open the colonic lumen with the use of CO2 insufflation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the how well the two methods distend the colon measured by MRI scanning 2. To further demonstrate the safe use of Klean Prep as the fluid of choice for CoDIR 3. To investigate how filling the colon with fluid changes its dimensions when repositioning the patient 4. To assess patient tolerance of different positions following instillation of fluid | — |
Countries
United Kingdom
Outcome results
None listed