Donor milk for improved neurodevelopmental outcomes

Conditions

Neurodevelopmental outcomes Neonatal Diseases Neurodevelopmental outcomes

Xu J, Shin J, McGee M, Unger S, Bando N, Sato J, Vandewouw M, Patel Y, Branson HM, Paus T, Pausova Z, O'Connor DL.

2022-10-019 citations

Higher Energy, Lipid, and Carbohydrate Provision to Very Low‐Birth‐Weight Infants Is Differentially Associated With Neurodevelopment at 18 Months, Despite Consistent Improvements in Weight Gain

Rosine Bishara, Michelle R. Asbury, Nalini Singhal, Nicole Bando, Nalini Singhal et al. (8 authors)

Journal of Parenteral and Enteral Nutrition2021-03-263 citations

10.1002/jpen.2072

Adiposity and Fat-Free Mass of Children Born with Very Low Birth Weight Do Not Differ in Children Fed Supplemental Donor Milk Compared with Those Fed Preterm Formula.

McGee M, Unger S, Hamilton J, Birken CS, Pausova Z, Kiss A, Bando N, O'Connor DL.

2020-02-0112 citations

10.1093/jn/nxz234

Optimizing the growth of very-low-birth-weight infants requires targeting both nutritional and nonnutritional modifiable factors specific to stage of hospitalization.

Asbury MR, Unger S, Kiss A, Ng DVY, Luk Y, Bando N, Bishara R, Tomlinson C, O'Connor DL, GTA-DoMINO Feeding Group.

2019-12-0123 citations

10.1093/ajcn/nqz227

Postdischarge Feeding of Very-low-birth-weight Infants: Adherence to Nutrition Guidelines.

Francis J, Unger S, Bando N, Vance A, Gibbins S, Kiss A, Church P, Sellen D, O'Connor DL, GTA-DoMINO Feeding Group.

2018-09-019 citations

10.1097/mpg.0000000000002041

Independent of Birth Mode or Gestational Age, Very-Low-Birth-Weight Infants Fed Their Mothers' Milk Rapidly Develop Personalized Microbiotas Low in Bifidobacterium.

Butcher J, Unger S, Li J, Bando N, Romain G, Francis J, Mottawea W, Mack D, Stintzi A, O'Connor DL.

2018-03-0122 citations

10.1093/jn/nxx071

Neonatal Morbidity Count Is Associated With a Reduced Likelihood of Achieving Recommendations for Protein, Lipid, and Energy in Very Low Birth Weight Infants: A Prospective Cohort Study.

Ng DVY, Unger S, Asbury M, Kiss A, Bishara R, Bando N, Tomlinson C, Gibbins S, O'Connor DL, GTA-DoMINO Feeding Group.

2017-12-1915 citations

10.1177/0148607117710441

Factors Associated with In‐Hospital Growth Trajectories of Very Low Birth Weight (VLBW) Infants

Michelle R. Asbury, Sharon Unger, Dawn VY. Ng, Alex Kiss, Yunnie Luk et al. (9 authors)

The FASEB Journal2017-04-01

10.1096/fasebj.31.1_supplement.316.5

Effect of Supplemental Donor Human Milk Compared With Preterm Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18 Months: A Randomized Clinical Trial.

O'Connor DL, Gibbins S, Kiss A, Bando N, Brennan-Donnan J, Ng E, Campbell DM, Vaz S, Fusch C, Asztalos E, Church P, Kelly E, Ly L, Daneman A, Unger S, GTA DoMINO Feeding Group.

2016-11-01173 citations

10.1001/jama.2016.16144

DoMINO: Donor milk for improved neurodevelopmental outcomes.

Unger S, Gibbins S, Zupancic J, O'Connor DL.

2014-05-1339 citations

10.1186/1471-2431-14-123

Interventions

Treatment Group: Infants randomised to the intervention group will receive donor milk when mothers' own milk is unavailable. Infants will continue to receive donor milk after transfer

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Day 1 to 4 of life 2. Less than 1500 g birth weight 3. Enteral feeding is expected to be initiated in the first 7 days of life

Exclusion criteria

Exclusion criteria: 1. Infants with serious congenital or chromosomal anomalies that may contribute to serious developmental outcome 2. Asphyxia (hypoxia or ischaemia) as defined by all of: 2.1. Severe metabolic or mixed acidaemia (pH less than 7.00 or base deficit less than -16) on an umbilical cord arterial blood sample or neonatal blood gas within first hour of life 2.2. Apgar score of 0 - 3 for greater than 5 minutes 2.3. Multi-organ system dysfunction within 72 hours of birth 3. Enrolment in any other clinical study affecting nutritional management during the feeding intervention 4. Reasonable potential that the infant will be transferred to a Neonatal Intensive Care Unit (NICU) or Level II NICU where the study protocol will not be continued

Design outcomes

Primary

Measure	Time frame
Cognitive composite score on the Bayley Scales of Infant and Toddler Development-III (BSID-III) at 18 - 24 months corrected age.	—

Secondary

Measure	Time frame
1. Morbidity/mortality 2. Composite of death, NEC, late onset sepsis, chronic lung disease or severe retinopathy of prematurity (ROP) 3. Growth (Secondary): 3.1. Weight (g/kg/d), length (mm/wk) and head circumference (mm/wk) gain 3.2. Weight-for-age, length-for-age and head circumference-for-age z-scores 4. Development (Secondary): 4.1. Language and motor composite scores on the BSID-III at 18-24 months corrected age 5. Feeding Tolerance and Nutrient Intake (Exploratory) 5.1. Days to full enteral feeding (150 ml/kg/d) 5.2. Days feedings withheld 5.7. Estimated energy and select nutrient intakes (protein, fat, calcium, phosphorus, iron, zinc) 6. Growth and Breastfeeding (Exploratory) 6.1. Weight-for-age, length-for-age and head circumference-for-age z-scores to 18-24 months corrected age 6.2. Duration (days) of human milk feeding (mothers? own milk) 6.3. Exclusivity of human milk feeding (mothers? own milk) at each infant?s 4, 6 and 12 months corrected age 7. Cost effectiveness (medical and non-medical) from a societal perspective (Exploratory) Added 20/09/2017: 8. Gut microbiome characterization (Exploratory	—

Measure

Time frame

1. Morbidity/mortality 2. Composite of death, NEC, late onset sepsis, chronic lung disease or severe retinopathy of prematurity (ROP) 3. Growth (Secondary): 3.1. Weight (g/kg/d), length (mm/wk) and head circumference (mm/wk) gain 3.2. Weight-for-age, length-for-age and head circumference-for-age z-scores 4. Development (Secondary): 4.1. Language and motor composite scores on the BSID-III at 18-24 months corrected age 5. Feeding Tolerance and Nutrient Intake (Exploratory) 5.1. Days to full enteral feeding (150 ml/kg/d) 5.2. Days feedings withheld 5.7. Estimated energy and select nutrient intakes (protein, fat, calcium, phosphorus, iron, zinc) 6. Growth and Breastfeeding (Exploratory) 6.1. Weight-for-age, length-for-age and head circumference-for-age z-scores to 18-24 months corrected age 6.2. Duration (days) of human milk feeding (mothers? own milk) 6.3. Exclusivity of human milk feeding (mothers? own milk) at each infant?s 4, 6 and 12 months corrected age 7. Cost effectiveness (medical and non-medical) from a societal perspective (Exploratory) Added 20/09/2017: 8. Gut microbiome characterization (Exploratory

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Countries

Canada

Outcome results

None listed