Long-term mental and brain health effects of COVID among adult patients

Neuropsychiatric ‘long-COVID’ in adult patients (Phase 1)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN35268189

Enrollment

750

Registered

2022-09-08

Start date

2022-08-24

Completion date

Unknown

Last updated

2022-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Long term neuropsychiatric symptoms of COVID Nervous System Diseases

Interventions

The method of assessment will be an online survey, supplemented by subject’s electronic health record. The following data will be collected via the online survey: (i) demographic data

(ii) pre-COVID physical and mental health status

(iii) socioeconomic profile and social impact of COVID-19, including level of social deprivation and health behaviour (iv) clinical parameters of acute COVID-19 episode

(v) self reported symptoms checklist for ‘long-COVID’, which include items of neuropsychiatric dimensions e.g. cognitive complaint, fatigue, depression, anxiety, insomnia

(iv)neuropsychiatric symptoms scales of mood, anxiety, post-traumatic stress, sleep and fatigue symptoms (vii) brief online cognitive tests with focuses on attention and memory(a. One-back memory tes

b. Psychomotor vigilance test: the subjects are asked to press the button as quickly as possible when they see the display turn red

c. Digit symbol substitution test : subjects will be presented with symbols, and they are asked to search for the correct symbol-digit pairing from a list, and respond by choosing the paired digit)

d. finger tap test. Separately, we will ask for COVID group’s subjects’ consent to access their clinical data in relation to their clinical characteristics and treatment of COVID in th

2. The progre

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: COVID patients group 1. History of confirmed SARS-CoV-2 infection of any level of severity 2. SARS-CoV-2 infection occurred more than 1 year ago,before Omicron variant prevailed in Hong Kong in Feburary 2022 3. Aged between 18-65 years non-COVID control group 1. No history of SARS-CoV-2 infection confirmed by lateral-flow test or PCR 2. Matched with COVID patients group in terms of the following 5 characteristics: age, gender, ethnicity, pre-COVID medical and psychiatric comorbidities, and socioeconomic status

Exclusion criteria

Exclusion criteria: Unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Core neuropsychiatric symptom cluster(s) among COVID patients measured using self-reported questionnaires one year after initial infection.	—

Secondary

Measure	Time frame
1. Grey matter volume differences between COVID patients who suffer from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI, particularly in the olfactory cortex, limbic cortex, frontal cortex, and the brainstem one year after initial infection. 2. Differences in white matter integrity between COVID patients who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI, particularly in the olfactory cortex, limbic cortex, frontal cortex, and the brainstem one year after initial infection. 3. Differences in frequency of neuropsychiatric symptoms between COVID patients one year after initial infection and controls who have never been infected as measured by self-reported questionnaires. 4. Differences in HRQoL between COVID patients one year after initial infection and controls who have never been infected measured using self-reported questionnaires. 5. Correlation of clinical characteristics of acute COVID, as retrieved from the electronic health record, with core neuropsychiatric symptom clusters, as measured by self-reporting questionnaire. 6. Correlation of socioeconomic factors with core neuropsychiatric symptom cluster(s) as measured by self-reporting questionnaires. 7. Correlation of vaccination status (type/number of doses) with core neuropsychiatric symptom cluster(s) as measured by self-reporting questionnaires. 8. Differences in diffusivity and the index along the perivascular space (ALPS index) between COVID patients one year after initial infection who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI. 9. Differences in perfusion between COVID patients one year after initial infection who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI	—

Measure

Time frame

1. Grey matter volume differences between COVID patients who suffer from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI, particularly in the olfactory cortex, limbic cortex, frontal cortex, and the brainstem one year after initial infection. 2. Differences in white matter integrity between COVID patients who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI, particularly in the olfactory cortex, limbic cortex, frontal cortex, and the brainstem one year after initial infection. 3. Differences in frequency of neuropsychiatric symptoms between COVID patients one year after initial infection and controls who have never been infected as measured by self-reported questionnaires. 4. Differences in HRQoL between COVID patients one year after initial infection and controls who have never been infected measured using self-reported questionnaires. 5. Correlation of clinical characteristics of acute COVID, as retrieved from the electronic health record, with core neuropsychiatric symptom clusters, as measured by self-reporting questionnaire. 6. Correlation of socioeconomic factors with core neuropsychiatric symptom cluster(s) as measured by self-reporting questionnaires. 7. Correlation of vaccination status (type/number of doses) with core neuropsychiatric symptom cluster(s) as measured by self-reporting questionnaires. 8. Differences in diffusivity and the index along the perivascular space (ALPS index) between COVID patients one year after initial infection who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI. 9. Differences in perfusion between COVID patients one year after initial infection who suffers from core neuropsychiatric symptom cluster(s) and those who do not as measured by MRI

—

Countries

Hong Kong

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026