Can local anaesthetic injection reduce pain in knee arthroplasty?

A randomised controlled trial investigating the efficacy of local anaesthetic infiltration during total knee replacement surgery at reducing post operative pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35062232

Enrollment

Registered

2012-01-03

Start date

2011-10-24

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain following knee arthroplasty Signs and Symptoms Pain in joint

Interventions

Patients undergoing knee arthroplasty will be randomly allocated to receive local infiltration analgesia or saline. Pain following surgery will be measured. 150ml of 0.1% levobupivacaine + 1:200 000

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Undergoing total knee replacement surgery under spinal anaesthesia at Leicester General Hospital 2. Ability to give informed consent to their involvement in the trial 3. Male and female participants 4. Aged 18 - 100

Exclusion criteria

Exclusion criteria: 1. Pre-existing chronic pain 2. Use of regular strong opiate medication prior to surgery; specifically, patients using opiate patches or Gabapentin

Design outcomes

Primary

Measure	Time frame
Pain at rest measured using the visual analogue scale.	—

Secondary

Measure	Time frame
1. Quantity of opiate medication required 2. Length of hospital stay 3. Pain during exercise measured using the visual analogue scale	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026