Subdermal implantation of the collagen-elastin-matrix Matriderm® to improve profile and skin structure of degenerative changes in the midface region [Subkutaner einsatz der kollagen-elastin-matrix Matriderm® zur verbesserung von profil und hautstruktur bei degenerativen veränderungen des mittelgesichtes]

Subdermal implantation of the collagen-elastin-matrix Matriderm® to improve profile and skin structure of degenerative changes in the midface region: a non-randomised single arm clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN35051281

Enrollment

Registered

2009-07-31

Start date

2008-05-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative structure of profile and/or skin quality in the mid-face, caused by disease or ageing Skin and Connective Tissue Diseases Skin quality in the mid-face

Interventions

Step 1: Subdermal laminar implantation of a collagen-elastin-matrix on the upper arm Step 2: Subdermal laminar implantation of a collagen-elastin-matrix on the mid-face region Skin biopsies (upper ar

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults aged 40 - 65 years, either sex

Exclusion criteria

Exclusion criteria: 1. Severe allergies 2. Severe acute or chronic diseases 3. Skin infections

Design outcomes

Primary

Measure	Time frame
Clinical outcome of mid-face region, measured at month 8 after step 1 (upper arm).	—

Secondary

Measure	Time frame
Clinical, histological and cutometric outcome upper arm, measured at month 14 after step 1 (upper arm).	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026