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Evaluation of oxygen and serum levels of growth hormone and bone growth after orthodontic treatment in growing patients

Evaluation of oxygen saturation and serum levels of growth hormone and bone growth mediators after rapid maxillary expansion in growing patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN34963223
Enrollment
120
Registered
2023-05-31
Start date
2016-11-18
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posterior crossbite Oral Health

Interventions

The changes in growth hormone (GH) levels that the patients will show at the two timepoints will be first compared to a control group of the same age and this will allow the evaluation of significant

Sponsors

University of Alberta
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Good general health according to medical history and clinical examination 2. Maxillary transverse discrepancy (skeletal discrepancy) with or without unilateral posterior crossbite 3. Age between 7 and 10 years old (this age range was chosen to prevent bias in terms of pubertal peak growth since at this age it is assumed males and females have not had it yet) 4. Body mass index (BMI) is healthy (not below the 25th percentile and not above the 75th percentile) according to age.

Exclusion criteria

Exclusion criteria: Patients in the pubertal growth spurt

Design outcomes

Primary

MeasureTime frame
Effects of rapid maxillary expansion on breathing measured by analyzing CBCTs, photos, airway measures and questionnaires at T0, T12 months and T End

Secondary

MeasureTime frame
Blood measurement of Serum bone alkaline phosphatase, calcium, phosphorus and Vitamin D levels using standard laboratory procedures at T0, T12 months and T End

Countries

Canada, Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026