The comparison of two dental techniques used to treat upper front adult teeth which have become infected or painful following accidental damage

Revascularisation versus mineral trioxide aggregate in the Management of non-vital immature permanent incisors in a young population: a randomised controlled trial (pilot study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34934882

Enrollment

Registered

2012-10-16

Start date

2010-10-01

Completion date

Unknown

Last updated

2020-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-vital immature permanent central incisors (upper front adult teeth) Oral Health

Interventions

Participants are randomised into 2 groups via computer generated random allocation. Allocation concealment by sealed serially numbered opaque envelopes. Pre-operative Assessment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Between 7 and 25 years of age 2. Have no significant medical history 3. Cooperative in the dental chair 4. Able to commit to the recall schedules prescribed by the study 5. Have one or more traumatised non-vital permanent maxillary central incisors with incomplete root development

Exclusion criteria

Exclusion criteria: 1. Have a medical history that may complicate treatment 2. Have a medical history for which the study procedures may place the patient at increased risk 3. Have a diagnosis of avulsion or severe intrusion following dental trauma 4. Permanent maxillary central incisors for treatment must not: 4.1. Be less than half formed 4.2. Have anatomical complexity (such as dens invaginatus) 4.3. Have horizontal or vertical root fractures present 4.4. Have evidence of root resorption

Design outcomes

Primary

Measure	Time frame
1. A satisfactorily restored tooth 2. An asymptomatic tooth 3. Absence of signs of failure of treatment (e.g. sinus, swelling, mobility) 4. Evidence of periapical healing 5. Absence of root resorption 6. Patient satisfaction	—

Secondary

Measure	Time frame
1. Development and maturation of the root following pulp revascularisation 2. Reduction in the size of the periapical radiolucency between pre- and post-treatment radiographs 3. In the case of pulp revascularisation - a positive response to vitality testing	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026