Can an extract of a patient's own blood prevent loss of tissue in the tooth socket after wisdom tooth extraction?

Tridimensional alveolar ridge preservation after exodontia with leukocyte- and platelet-rich fibrin (L-PRF): A split-mouth randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34932978

Enrollment

Registered

2020-04-22

Start date

2019-04-01

Completion date

Unknown

Last updated

2022-01-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preservation of structure after upper third molar extraction Oral Health

Interventions

The randomization of the side of the jaw (right tooth #18 and left tooth #28) that received the L-PRF and the blood clot was determined by a researcher using the "RANDBETWEEN" function of Microsoft Ex

column #2 use of L-PRF or blood clot) assigning the type of intervention to be applied in each alveolus. An oral surgeon with more than 10 years of experience performed the extraction

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Men or women aged over 18 years 2. Indications for extraction of upper third molars for orthodontic treatment or difficult hygiene control at the Dental Clinic Center of the Universidad Austral de Chile (Valdivia, southern Chile) 3. Healthy, ASA I, without systemic diseases 4. Non-smoker 5. Oral hygiene index over 80% according to WHO criteria 6. Absence of caries or teeth in a radicular state 7. Participation approved through informed consent

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Chronic periodontal disease 3. Chronic apical pathology 4. Receiving systemic or local pharmacological treatment in the last 3 months with antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs) or glucocorticoids 5. Acute infection of the tooth to be extracted 6. Receiving treatment with anticoagulants

Design outcomes

Primary

Measure	Time frame
Volume in mm3 of alveolar wound calculated from 3-dimensional images of plaster models obtained on both sides of the extracted third maxillary molars 7 days and 3 months after the extraction	—

Secondary

Measure	Time frame
1. Mesiodistal dimension of alveolar wound, defined as the limit between keratinized gum (healthy tissue) and the presence of fibrin or blood clot, measured by a second investigator using a North Carolina periodontal probe (Hu-FriedyTM. Hu-Friedy Co. Frankfurt, Germany) at 7 days and 3 months post-extraction 2. Vestibulopalatine dimension of alveolar wound, defined as the limit between keratinized gum (healthy tissue) and the presence of fibrin or blood clot, measured by a second investigator using a North Carolina periodontal probe (Hu-FriedyTM. Hu-Friedy Co. Frankfurt, Germany) at 7 days and 3 months post-extraction	—

Measure

Time frame

1. Mesiodistal dimension of alveolar wound, defined as the limit between keratinized gum (healthy tissue) and the presence of fibrin or blood clot, measured by a second investigator using a North Carolina periodontal probe (Hu-FriedyTM. Hu-Friedy Co. Frankfurt, Germany) at 7 days and 3 months post-extraction 2. Vestibulopalatine dimension of alveolar wound, defined as the limit between keratinized gum (healthy tissue) and the presence of fibrin or blood clot, measured by a second investigator using a North Carolina periodontal probe (Hu-FriedyTM. Hu-Friedy Co. Frankfurt, Germany) at 7 days and 3 months post-extraction

—

Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026