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The effects of pomegranate mouth rinses on oral health

Pomegranate in mouth rinses on de novo plaque formation: a double-blind clinical study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN34881910
Enrollment
15
Registered
2025-09-24
Start date
2015-12-01
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of supragingival biofilm accumulation on tooth surfaces in healthy subjects Oral Health

Interventions

Preparation of the mouth rinses Initially, 1ml of essential oil was diluted in 9 ml of distilled water (1:9), preparing a 10% mixture (V/V) (Pg solution). A mouth rinse containing just distilled water

Sponsors

Universidade de Fortaleza
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Dental students 2. At least 24 natural teeth 3. No signs of periodontitis 4. No caries or extensive dental restorations 5. No exposure to systemic antibiotic treatment during the past 6 months 5. Do not routinely use chemical plaque control

Exclusion criteria

Exclusion criteria: 1. An orthodontic appliance 2. Medical disorders 3. Smokers 4. Pregnant women

Design outcomes

Primary

MeasureTime frame
Plaque index (PLI) on the tooth surface was measured using a fuchsine-revealing solution and a periodontal probe after 3 days of product use

Secondary

MeasureTime frame
Clinically significant adverse effects, including abscesses, mucosal ulcerations, or hypersensitivity reactions, were measured using data collected through clinical inspection and patient reports by the end of the study

Countries

Brazil

Contacts

Public ContactSérgio Luís da Silva Pereira
luiss@unifor.br+55 (85) 3477-3259

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026