Non-small cell lung cancer and mesothelioma Cancer Non-small cell lung cancer and mesothelioma
Conditions
Interventions
Patients are randomised to receive one of the following interventions:
1. Morphine
2. Acupuncture
3. Morphine and acupuncture
After completing baseline assessments patients will undergo treatment
Sponsors
Royal Marsden Hospital (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with a diagnosis of Non Small Cell Lung Cancer (NSCLC) and mesothelioma and breathless at rest with at least a Visual Analogue Scale (VAS) score >/= 4, or breathlessness at rest
Exclusion criteria
Exclusion criteria: 1. Recent acupuncture in the last four weeks 2. Contraindications to acupuncture e.g bleeding abnormality or anticoagulation 3. Current use of morphine in any form (oral or nebuliser) at study entry 4. Untreated reversible anaemia, pleural effusion, pulmonary embolism, pneumonia, ascites, or superior vena cava obstruction, if treatment appropriate 5. Pregnancy 6. Commenced oral or inhaled steroids or changed dose within one week of the start of the study 7. Chemotherapy or radiotherapy or change in hormonotherapy in the last four weeks
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Measures of anxiety, relaxation, other subjective variables (Lar scales) 2. Respiratory rate and lung function tests (Forced Expiratory Volume [FEV], Partial Expiratory Flow Rate [PEFR]) 3. Hospital Anxiety and Depression (HAD) Scale 4. Quality of Life (QOL) changes between baseline and 7 days | — |
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of acupuncture for relief of breathlessness in lung cancer | — |
Countries
United Kingdom
Outcome results
None listed