Study of children and young people who may be experiencing long COVID

Children and young people with long COVID (CLoCk) study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN34804192

Enrollment

30000

Registered

2021-04-19

Start date

2021-04-12

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) Infections and Infestations

Interventions

Setting/population: Public Health England (PHE) has been conducting national surveillance of SARS-CoV-2 since the start of the pandemic in England. PHE receive daily electronic notifications of all SA

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants must be aged 11-17 years and have had a recorded positive SARS-CoV-2 test 2. These will be matched by age, sex and region to include 11-17-year-olds who have had a recorded negative SARS-CoV-2 test (negative controls)

Exclusion criteria

Exclusion criteria: Age range outside of study design

Design outcomes

Primary

Measure	Time frame
1. Physical symptoms assessed using a checklist based on items from the ISARIC Paediatric COVID-19 questions at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 2. Emotional and mental health measured using the Strengths and Difficulties Questionnaire at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 3. Quality of life/functioning measured using the EQ-5D-Y at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 4. Fatigue measured using the Chalder Fatigue Questionnaire at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 5. Wellbeing assessed using the short version of the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 6. Loneliness assessed using the adapted UCLA 4 items at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test	—

Measure

Time frame

1. Physical symptoms assessed using a checklist based on items from the ISARIC Paediatric COVID-19 questions at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 2. Emotional and mental health measured using the Strengths and Difficulties Questionnaire at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 3. Quality of life/functioning measured using the EQ-5D-Y at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 4. Fatigue measured using the Chalder Fatigue Questionnaire at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 5. Wellbeing assessed using the short version of the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test 6. Loneliness assessed using the adapted UCLA 4 items at any or all of 3, 6, 12 and 24 months post-COVID test depending on the time of test

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, United Kingdom

Contacts

Public ContactMichael Lattimore

Clock@phe.gov.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 14, 2026