The effect of myocardial ischaemia on pro-inflammatory cytokines and stress proteins

The effect of myocardial ischaemia on pro-inflammatory cytokines and stress proteins: a randomised controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34742708

Enrollment

Registered

2003-09-12

Start date

2002-09-02

Completion date

Unknown

Last updated

2021-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular: Myocardial ischaemia Circulatory System Myocardial ischaemia

Interventions

Treadmill Stress vs Pharmacological Stress (Dobutamine)

Eligibility

Inclusion criteria

Inclusion criteria: Added 24 July 2008: Patients with greater than or equal to 1 flow-limiting coronary artery stenosis, stable symptoms & ST segment depression on exercise testing (if there is one prior to angiogram)

Exclusion criteria

Exclusion criteria: Added 24 July 2008: Control subjects with low pre-exercise test probability of CAD & negative exercise test result (age- / sex- / body mass index- matched).

Design outcomes

Primary

Measure	Time frame
To assess the plasma levels of interleukin-6 (IL6), tumour necrosis factor alpha (TNFa), tissue factor (TF) and heat shock protein 60 (hsp60). Two stress methods will be employed. While IL6 can also be increased with perpheral muscle stress produced by exercise, dobutamine could induce a smaller ischaemic burden. The two tests therefore will be performed in each patient in order to link cytokines to ischaemia alone.	—

Measure

Time frame

To assess the plasma levels of interleukin-6 (IL6), tumour necrosis factor alpha (TNFa), tissue factor (TF) and heat shock protein 60 (hsp60). Two stress methods will be employed. While IL6 can also be increased with perpheral muscle stress produced by exercise, dobutamine could induce a smaller ischaemic burden. The two tests therefore will be performed in each patient in order to link cytokines to ischaemia alone.

—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026