Vitamin K deficiency in the pathogenesis of osteoporosis in primary biliary cirrhosis (PBC)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34566366

Enrollment

Registered

2004-01-23

Start date

1998-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis Musculoskeletal Diseases Osteoporosis and primary biliary cirrhosis

Interventions

i. Vitamin K supplementation ii. No vitamin K supplementation

Eligibility

Inclusion criteria

Inclusion criteria: Sixty out-patients with PBC will be recruited from the Royal Hallamshire Hospital Liver Service.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Should Vitamin K supplementation be found to alter the course of bone loss in PBC patients it would provide a very cost effective therapeutic intervention. The research may have additional implications for healthcare provision in other areas of metabolic bone disease.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026