Alterations of immunologic mediators during severe sepsis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN34508816

Enrollment

Registered

2006-06-13

Start date

2006-06-01

Completion date

Unknown

Last updated

2019-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe sepsis Infections and Infestations Sepsis

Interventions

Daily blood samples for 7 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older 2. Agreement with study procedures, informed consent 3. Fulfilling 3 out of 4 criteria of a systemic inflammatory response syndrome (SIRS) 4. Suspected or proven infection 5. Two or more sepsis-induced organ dysfunctions 6. Start of first sepsis-induced organ dysfunction within the last 36 hours

Exclusion criteria

Exclusion criteria: 1. Non-agreement with study procedures 2. Sign of severe sepsis for more than 36 hours 3. Chronic immuno-compromizing diseases 4. Chronic therapy with anti-inflammatory drugs 5. Non-curable cancer diseases 6. Chronic renal failure with hemodialysis 7. Pregnant or breast feeding

Design outcomes

Primary

Measure	Time frame
Alterations of immunologic parameters	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026