Sickle cell disease with vaso-occlusive crisis Haematological Disorders Sickle-cell disorders
Conditions
Interventions
Use of IV paracetamol in combination with morphine versus use of placebo with morphine:
Group A (standard treatment): morphine (weight of the child multiplied by constant 0.5 = *mg of morphine) and pl
no standard period. The period of hospital stay will be compared later to see if there is any reduction by adding IV paracetamol to morphine treatment. The patient will have liver function tests perfo
Sponsors
Sultan Qaboos University (Oman) - College of Medicine and Health Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All sickle cell disease (SCD) children (aged 2 - 13 years, either sex) admitted with vaso-occlusive crisis (VOC) in B2 (blue two) ward of Sultan Qaboos University Hospital (SQUH)
Exclusion criteria
Exclusion criteria: 1. Children aged less than one year 2. Children with fever of more than 38.5°C 3. Children with prior side effects of morphine 4. Children with prior history of side effects of paracetamol 5. Children with severe jaundice or severe liver impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the amount of morphine and duration of hospitalisation, assessed on a daily basis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessed on a daily basis: 1. Reduction in duration of hospital stay (days) for pain relief 2. Reduction in pain severity on a scale of 1 - 10, which will be assessed each shift 3. Reduction of morphine requirements 4. Reduction in morphine side effects namely: prurities, nausea/vomiting, urinary retention | — |
Countries
Oman
Outcome results
None listed