The effect of locally applied autologous platelet-rich fibrin sealant on woundhealing

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34481461

Enrollment

Registered

2005-10-06

Start date

2005-08-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholelithiasis Digestive System Cholelithiasis

Interventions

Surgical wounds treated with trial product (platelet-rich fibrin) or control.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Consecutive patients undergoing elective laparoscopic cholecystectomy, over 18 years old who have given written and verbal informed consent.

Exclusion criteria

Exclusion criteria: 1. Not Danish-speaking 2. Demential 3. Pregnant or lactating women 4. Fertile women not using contraception 5. Patients on aspirin (acetylsalicylic acid [ASA]) or anticoagulants less than 7 days before surgery 6. Patients suffering from anaemia or coagulation disorders 7. Patients suffering from incompensated heart or lung disease

Design outcomes

Primary

Measure	Time frame
Collagen synthesis	—

Secondary

Measure	Time frame
1. Woundstrength 2. Production of type I and III collagen mRNA 3. Histology 4. Growthfactors 5. Unwanted effects	—

Countries

Denmark

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 31, 2026