Understanding patients with elevated pulmonary arterial pressure

Phenotyping individuals with elevated mean pulmonary arterial pressure and elevated pulmonary vascular resistance in the United Kingdom

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN34481181

Enrollment

2000

Registered

2021-06-09

Start date

2009-01-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary arterial hypertension Circulatory System Pulmonary hypertension

Interventions

This retrospective, observational, multi-center study aims to describe patient and clinical characteristics, biomarkers, therapies, and prognosis of patients categorized into 3 groups based on their M

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged =18 years at time of the first right heart catheter (RHC) procedure within the eligibility period 2. =1 RHC procedure in one of the pulmonary hypertension specialist or approved centers within the eligibility period

Exclusion criteria

Exclusion criteria: 1. Missing value for mean Pulmonary Arterial Pressure or Pulmonary Vascular Resistance at the right heart catheter (RHC) procedure 2. Received any Pulmonary arterial hypertension medications before the first RHC procedure 3. Lung and/or heart transplant any time before the first RHC procedure 4. Enrolled in any interventional clinical trial with an investigational product within the 3 months prior to, or at the time of, the first RHC procedure within the eligibility period

Design outcomes

Primary

Measure	Time frame
1. Hospitalization measured using the incidence of inpatient hospitalization events due to any cause anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint 2. Mortality rates measured using the time to all-cause mortality anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint	—

Measure

Time frame

1. Hospitalization measured using the incidence of inpatient hospitalization events due to any cause anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint 2. Mortality rates measured using the time to all-cause mortality anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint

—

Secondary

Measure	Time frame
1. Quality of life measured using the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) or emPHasis-10 questionnaire anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint 2. Progression to Pulmonary Hypertension measured using the date of Right Heart Catheterisation (RHC) anytime during the observation period (01/01/2009 to 01/03/2020) when the measured mPAP is =25 mmHg for the first time after the index RHC from retrospective HES and ONS or ISD data collection at a single timepoint	—

Measure

Time frame

1. Quality of life measured using the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) or emPHasis-10 questionnaire anytime during the observation period (01/01/2009 to 01/03/2020) from retrospective HES and ONS or ISD data collection at a single timepoint 2. Progression to Pulmonary Hypertension measured using the date of Right Heart Catheterisation (RHC) anytime during the observation period (01/01/2009 to 01/03/2020) when the measured mPAP is =25 mmHg for the first time after the index RHC from retrospective HES and ONS or ISD data collection at a single timepoint

—

Countries

England, Scotland, United Kingdom

Contacts

Public ContactIvy Wanjiku Dakouri

ivy.wanjiku@nhs.net+44 (0)2073177544

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 27, 2026