Control of periodontal inflammation, systemic inflammatory responses and cognitive decline in Alzheimer?'s disease

Control of periodontal inflammation, systemic inflammatory responses and cognitive decline: a comparative study of standard oral care versus periodontal care

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34471493

Enrollment

Registered

2013-08-16

Start date

2011-11-22

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis and disease progression in Alzheimer?'s disease Nervous System Diseases Alzheimer disease

Interventions

Recruited individuals are stratified for gender and randomised into either a periodontal care or a standard care group using a random number table. Provision of oral hygiene instruction using a Braun

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 70 years or older, either sex 2. Amnestic according to Consortium to Establish a Registry for Alzheimer's Disease (CERAD) cognitive battery norms 3. Mini?Mental State Examination (MMSE) score range between 24-30 4. Geriatric Depression Scale less than/equals 4/5 5. Clinical Dementia rating scale score of less than/equals 0.5 6. Participants should be nonsmoking, in good general health and English speaking in order to allow valid cognitive assessment to take place 7. Willing and able to participate in study

Exclusion criteria

Exclusion criteria: 1. Less than 70 years old 2. Recent change in relevant medication 3. Current or recent smoker. 4. With 8 teeth or less 5. Not deemed sufficiently fit to undergo operative dental treatment including extractions 6. Recent active periodontal treatment 7. Reporting a history of local oropharyngeal radiotherapy resulting in oral dryness

Design outcomes

Primary

Measure	Time frame
Feasiblity and effectiveness of periodontal treatment at improving oral health in people with mild cognitive impairment (primary outcome A: changes in plaque scores, probing depths and bleeding scores), measured at 6-7 weeks	—

Secondary

Measure	Time frame
1. Levels of circulating proinflammatory cytokines (CRP and IL-6) 2. Rate of cognitive decline (change in CERAD score in 6 weeks; secondary outcome B change in rate of conversion to dementia over 1 year) 3. Whether there is a shared complex inflammatory marker for periodontitis and mild cognitive impairment and whether change in this marker set predicts response to therapy (shared marker set, predictive value of marker set) Measured at 6 months and final assessment at one year.	—

Measure

Time frame

1. Levels of circulating proinflammatory cytokines (CRP and IL-6) 2. Rate of cognitive decline (change in CERAD score in 6 weeks; secondary outcome B change in rate of conversion to dementia over 1 year) 3. Whether there is a shared complex inflammatory marker for periodontitis and mild cognitive impairment and whether change in this marker set predicts response to therapy (shared marker set, predictive value of marker set) Measured at 6 months and final assessment at one year.

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026