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Testing of iodine solution to fight bacteria in unsuccessfully treated root canals

Evaluation of the efficacy of iodine potassium iodide IKI irrigating solution in endodontic treatment (in-vivo bacteriologic and radiographic study)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN34453184
Enrollment
90
Registered
2024-04-18
Start date
2022-05-01
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Single-rooted teeth with periapical lesions Oral Health

Interventions

The applied treatments included first Sodium hypochlorite (NaOCl) then the Iodine-Potassium Iodide (IKI) Solution. Two concentrations of IKI were used: 2% and 5%. In the control group, only Sodium hyp

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 65 years 2. Patients were referred to the Endodontic Department with the presence of apical lesions. 3. The patients with signs of asymptomatic periapical periodontitis such as minor percussion pain, or large untreated caries or fractures of the root/crown on one or more maxillary or mandibular anterior (central, lateral and premolar). 4. Periapical lesions <5*5mm which were verifier radiographed.

Exclusion criteria

Exclusion criteria: 1. Presence of systemic diseases that compromised general immune status 2. Pregnant females 3. Patients with preoperative anxiety 4. Patients who received antibiotic therapy within the past 3 months 5. Open-apex teeth 6. Teeth with multicanals 7. Internal or external resorptions 8. Patients with advanced periodontitis (more than 5mm periodontal attachment and bone loss) 9. Teeth that were unsuitable for single-visit treatment, containing moist canals with exudation or pus

Design outcomes

Primary

MeasureTime frame
Bacterial count was determined by culturing the samples on nutrient agar plates for 48 h at 37°C in aerobic conditions, followed by counting colonies

Secondary

MeasureTime frame
Monitor the healing of apical periodontitis radiographically for 12 months

Countries

Syria

Contacts

Public ContactMeerna SARKEES
mirna2.sarkis@damascusuniversity.edu.sy+963 955103481

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026