Does an intervention with a healthy lifestyle change taste perception and smell detection?

Changes in taste perception and smell detection after a healthy lifestyle intervention: a randomized and controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN34388605

Enrollment

Registered

2019-12-13

Start date

2019-12-20

Completion date

Unknown

Last updated

2022-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Taste-smell Not Applicable

Interventions

This is a parallel randomized controlled trial including 60 participants (30 people in the intervention group and 30 people in the control group). Participants will be randomly assigned to the control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Volunteers recruited from the general population 2. Between 30 and 65 years old 3. BMI between 23 and 35 kg/m2

Exclusion criteria

Exclusion criteria: 1. Diseased 2. Diabetics 3. Immunodeficiency or HIV-positive status 4. Liver cirrhosis or chronic renal failure 5. Serious psychiatric disorders: schizophrenia, bipolar disease, eating disorders, depression, etc 6. Any severe co-morbid condition 7. Alcohol abuse or addition 8. History of major organ transplantation 9. Concurrent therapy with immunosuppressive drugs or cytotoxic agents 10. Current treatment with systemic corticosteroids 11. Current use of weight loss medication 12. Patients with an acute infection or inflammation 13. Pregnant or breastfeeding women 14. Any other condition that may interfere with the completion of the study protocol

Design outcomes

Primary

Measure	Time frame
1. Taste perception measured by a validated test (for sweet, salty, bitter, acid and umami flavors) at baseline and after intervention 2. Smell detection measured by a validated test called “Sniffin´Sticks” at baseline and after intervention	—

Secondary

Measure	Time frame
1. Blood pressure measured at baseline and after intervention 2. Weight, height, waist circumference and body composition by bioimpedance measured at baseline and after intervention 3. Food intake and adherence to the Mediterranean diet measured using the 14-item Mediterranean diet adherence PREDIMED scale at baseline and after intervention 4. Physical activity measured using the short form of the Minnesota physical activity questionnaire at baseline and after intervention 5. Sleep characteristics measured using the Pittsburgh Sleep Quality Index questionnaire at baseline and after intervention 6. Chronotype measured using the Horne and Östberg questionnaire at baseline and after intervention 7. Cognitive function measured using some tests (TMT-A, TMT-B, COWAT, Wechsler Adult Intelligence Scale-III) at baseline and after intervention	—

Measure

Time frame

1. Blood pressure measured at baseline and after intervention 2. Weight, height, waist circumference and body composition by bioimpedance measured at baseline and after intervention 3. Food intake and adherence to the Mediterranean diet measured using the 14-item Mediterranean diet adherence PREDIMED scale at baseline and after intervention 4. Physical activity measured using the short form of the Minnesota physical activity questionnaire at baseline and after intervention 5. Sleep characteristics measured using the Pittsburgh Sleep Quality Index questionnaire at baseline and after intervention 6. Chronotype measured using the Horne and Östberg questionnaire at baseline and after intervention 7. Cognitive function measured using some tests (TMT-A, TMT-B, COWAT, Wechsler Adult Intelligence Scale-III) at baseline and after intervention

—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026