Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
Participants are randomized into three groups: an intervention group receiving real acupuncture, a control group receiving sham acupuncture, and a second control group receiving no acupuncture. A simp
Sponsors
Scleroseforeningen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older 2. Diagnosed with relapsing-remitting multiple sclerosis for a minimum of 2 years 3. Must be able to walk unassisted (equivalent to an EDSS of 6.5) 4. Must have been relapse-free for the past 3 months 5. If treated with disease-modifying medicine, treatment must have been unchanged for the past 3 months
Exclusion criteria
Exclusion criteria: 1. Significant co-morbidities (heart disease, diabetes, Mb. Crohn or other) which may affect the immune system 2. Has received acupuncture treatment within the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine plasma levels (IFN?, IL-1ß, IL-6, IL-8, IL-12p70, IL-13, TNFa, IL-10, IL-4, IL-2 and IL-17A) measured using the Mesoscale Multi-spot Assay System on blood samples taken at baseline, the day after the 4th treatment, the day after the final treatment, and at 4 weeks following the final treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Health-related quality of life (HRQoL) measured using the MS-specific Functional Assessment of Multiple Sclerosis (FAMS) instrument at baseline, after 4 weeks (following the last treatment), and at 4 weeks after the final treatment | — |
Countries
Denmark
Outcome results
None listed