Chronic kidney disease Urological and Genital Diseases Other disorders of kidney and ureter, not elsewhere classified
Conditions
Interventions
Forty patients will be assigned randomly to the following four groups to determine whether alkali and exercise together are more effective than alkali or exercise alone:
1. Standard clinical therapy o
Sponsors
University Hospitals of Leicester NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Chronic kidney disease (CKD) patients at CKD stages 4 to 5.
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years, either sex 2. Pregnancy 3. Physical disability sufficient to preclude participating in an exercise programme
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Changes in immune function - in vitro assessment of lymphocyte proliferation and neutrophil activation 2. Changes in body composition - dual energy X-ray absorptiometry (DEXA) scanning Measurements made at zero and 6 months (end of study). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in exercise tolerance - submaximal exercise testing (bicycle ergometry or treadmill exercise) to determine maximal oxygen uptake and lactate threshold 2. Muscle biopsies - in vitro evaluation of intracellular signalling pathways that regulate protein synthesis 3. Changes in cardiovascular function - blood pressure, pulse wave velocity, finometry 4. Changes in quality of life measures - Leicester Uraemic Symptoms Score Measurements made at zero and 6 months (end of study). | — |
Countries
United Kingdom
Outcome results
None listed