Supplementation with Multiple Micronutrients Intervention Trial

Conditions

Maternal and infant mortality and morbidity, and birth weight Pregnancy and Childbirth

Lidwina Priliani, Sukma Oktavianthi, Elizabeth L. Prado, Safarina G. Malik, Anuraj H. Shankar

PLoS ONE2020-08-077 citations

10.1371/journal.pone.0216848

Maternal Multiple Micronutrient Supplementation Stabilizes Mitochondrial DNA Copy Number in Pregnant Women in Lombok, Indonesia.

Priliani L, Prado EL, Restuadi R, Waturangi DE, Shankar AH, Malik SG.

2019-08-0118 citations

10.1093/jn/nxz064

Maternal multiple micronutrient supplementation and other biomedical and socioenvironmental influences on children's cognition at age 9-12 years in Indonesia: follow-up of the SUMMIT randomised trial.

Prado EL, Sebayang SK, Apriatni M, Adawiyah SR, Hidayati N, Islamiyah A, Siddiq S, Harefa B, Lum J, Alcock KJ, Ullman MT, Muadz H, Shankar AH.

2017-02-0163 citations

10.1016/s2214-109x(16)30354-0

Effect of Maternal Multiple Micronutrients Supplementation on the Apgar Score of Indonesian Neonates

William Jayadi Iskandar, Emily R. Smith, A. Aditiawarman, Mandri Apriatni, R Tjiong et al. (6 authors)

The FASEB Journal2015-04-011 citations

10.1096/fasebj.29.1_supplement.741.13

The effect of maternal multiple micronutrient supplementation on cognition and mood during pregnancy and postpartum in Indonesia: a randomized trial.

Prado EL, Ullman MT, Muadz H, Alcock KJ, Shankar AH, SUMMIT Study Group.

2012-03-1223 citations

10.1371/journal.pone.0032519

Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial.

Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) Study Group, Shankar AH, Jahari AB, Sebayang SK, Aditiawarman, Apriatni M, Harefa B, Muadz H, Soesbandoro SD, Tjiong R, Fachry A, Shankar AV, Atmarita, Prihatini S, Sofia G.

2008-01-01138 citations

10.1016/s0140-6736(08)60133-6

Interventions

Initial study: Prenatal supplementation with either iron and folate or with a multivitamin containing iron, folate, vitamins A, B1, B2, B6, B12, C, D and E, along with niacin, zinc, co

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pregnant women and their infants. Inclusion criteria: Confirmed pregnancy of any gestational age by physical exam or urine test and consenting to be involved in the study.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
1. Miscarriage 2. Stillbirth 3. Perinatal mortality 4. Neonatal mortality 5. Early neonatal mortality 6. Late neonatal mortality 7. Infant mortality 8. Maternal mortality 9. Preterm birth 10. Birthweight 11. Low birthweight	—

Secondary

Measure	Time frame
Current secondary outcome measures as of 31/12/2014: 1. Child motor, cognitive, and socio-emotional development and health and morbidity at 9-12 years 2. Child anthropometry and nutritional status at 9-12 years 3. Child hemoglobin concentration at 9-12 years 4. An adapted version of the Home Observation for the Measurement of the Environment (HOME) as an indicator of the household cognitive development environment at 9-12 years 5. Maternal socio-emotional status at 9-12 years 6. Child biochemical nutritional status and biochemical markers of stress and immune function at 9-12 years 7. Child activity level, physiologic regulation and anatomical complexity at 9-12 years Previous secondary outcome measures as of 03/03/2011: 1. Maternal Cognition and Mood 2. Child Motor, Cognitive, and Socio-Emotional Development and Health and Morbidity at age 42 months 3. Child Anthropometry and nutritional status, including dietary habits, at age 42 months 4. Child Hemoglobin concentration at age 42 months 5. An adapted version of the Home Observation for the Measurement of the Environment (HOME) as an indicator of the household cognitive development environment 6. Weight gain during pregnancy 7. Maternal biochemical nutritional status and biochemical markers of pregnancy progression Previous secondary outcome measures: 1. Hemoglobin levels a. At 36 weeks gestational age b. Within 1 week of birth c. At 12 weeks post-partum d. Within 1 month of enrollment by 1st, 2nd, and 3rd trimester of enrollment 2. Gestational age 3. Head circumference 4. Maternal and infant morbidity 5. Cause of death	—

Measure

Time frame

Current secondary outcome measures as of 31/12/2014: 1. Child motor, cognitive, and socio-emotional development and health and morbidity at 9-12 years 2. Child anthropometry and nutritional status at 9-12 years 3. Child hemoglobin concentration at 9-12 years 4. An adapted version of the Home Observation for the Measurement of the Environment (HOME) as an indicator of the household cognitive development environment at 9-12 years 5. Maternal socio-emotional status at 9-12 years 6. Child biochemical nutritional status and biochemical markers of stress and immune function at 9-12 years 7. Child activity level, physiologic regulation and anatomical complexity at 9-12 years Previous secondary outcome measures as of 03/03/2011: 1. Maternal Cognition and Mood 2. Child Motor, Cognitive, and Socio-Emotional Development and Health and Morbidity at age 42 months 3. Child Anthropometry and nutritional status, including dietary habits, at age 42 months 4. Child Hemoglobin concentration at age 42 months 5. An adapted version of the Home Observation for the Measurement of the Environment (HOME) as an indicator of the household cognitive development environment 6. Weight gain during pregnancy 7. Maternal biochemical nutritional status and biochemical markers of pregnancy progression Previous secondary outcome measures: 1. Hemoglobin levels a. At 36 weeks gestational age b. Within 1 week of birth c. At 12 weeks post-partum d. Within 1 month of enrollment by 1st, 2nd, and 3rd trimester of enrollment 2. Gestational age 3. Head circumference 4. Maternal and infant morbidity 5. Cause of death

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Countries

Indonesia

Outcome results

None listed