An investigation on spinal fluid in patients with sciatica-type or nerve-type pain of the lower limb

An investigation on cerebrospinal fluid (CSF) concentrations of PD-1 and PD-L1 and quantification of cellularity of CSF in patients with chronic radicular lumbar pain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN34007592

Enrollment

Registered

2019-07-04

Start date

2018-10-24

Completion date

Unknown

Last updated

2023-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic lower limb pain Nervous System Diseases

Interventions

Patients are undergoing pulsed radiofrequency treatment (PRF). CSF is taken at the time of the procedure (just before it is performed) via lumbar puncture with subsequent flow cytometry performed. It

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Chronic radicular pain 2. Scheduled to undergo pulsed radiofrequency treatment (PRF).

Exclusion criteria

Exclusion criteria: Coagulopathy

Design outcomes

Primary

Measure	Time frame
Presence of PD-1 and PD-L1 in the patients spinal fluid (as quantified by flow cytometry)	—

Secondary

Measure	Time frame
Change in pain score of patient at 3 month interview and use of Douleur Neuropathique pain questionnaire at baseline (day of procedure) and 3 months later (when back in clinic)	—

Countries

Ireland

Contacts

Public ContactDeborah Galvin

deborahgalvin@yahoo.ie+353 1 4163952

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026