Functional neurosurgery for drug addiction Surgery Functional neurosurgery
Conditions
Interventions
1. Radiofrequency ablation of the NAc
2. Different lesioning location and volumn within NAc in four groups
3. Abstinence from opioid use and adverse events related to operation
4. Neuropsychiatric fun
Sponsors
Ministry of Science and Technology (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Heroin abuse using 0.3 - 1.0 g daily for at least 3 years by intravenous injection with or without concomitant nasal inhalation 2. Failure of multiple other treatment modalities 3. Ages between 18 and 50 years, either sex 4. Completion of detoxification treatment preoperatively with no somatic symptoms of withdrawal and negative morphine urinalysis and naloxone tests
Exclusion criteria
Exclusion criteria: 1. Inability to give informed consent 2. Human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) virus carrier 3. Developmental delay, cognitive impairment, personality disorders and neuropsychiatric diseases other than addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abstinence from opioid use, measured by morphine urinalysis and naloxone testing in the fourth post-operative year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Complications in stereoctactic surgery (e.g fever, nausea/emesis, seizure, infection, intracranial haemorrhages) 2. Possible neuropsychiatric change related to NAc ablation: memory, motivation, emotion, olfactory sensation After operation, the secondary outcomes were measured at six month intervals and extended for four years. | — |
Countries
China
Outcome results
None listed