Randomised prospective study comparing epidural analgesia perioperatively and 24 hours preoperatively for the prevention of postoperative stump pain and phantom limb pain following major amputation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33846889

Enrollment

Registered

2004-09-30

Start date

2003-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Amputation Surgery Amputation

Interventions

Study group to be selected from patients scheduled for lower limb amputation who are randomised into two groups: 1. To commence epidural at time of surgery 2. To commence epidural 24hr prior to sur

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients above the age of 18 2. All patients undergoing scheduled lower limb amputation will be considered

Exclusion criteria

Exclusion criteria: 1. Non general anaesthetic (GA) 2. Emergency surgery 3. Unable to give consent 4. Contraindications to epidural 5. Anticoagulated

Design outcomes

Primary

Measure	Time frame
Pain scores to be assessed: 1. Immediately post-operatively. Subjective and objective scoring using a visual analogue score, and a record of morphine requirements for post-operative pain. 2. Phantom limb pain; assessed as present or absent at 3, 6 and 12 month follow up.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026