Evaluation of the efficacy of topical oestrogen therapy in the management of urinary dysfunction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33778440

Enrollment

432

Registered

2000-10-25

Start date

1999-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incontinence Urological and Genital Diseases Incontinence

Interventions

1. Active: Topical vaginal oestrogen in the form of vaginal slow releasing rings (Estring) 2. Control: Matching placebo

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Urinary dysfunction measured clinically (incontinence, nocturia, frequent voiding, urinary urgency) 2. Post-menopausal women

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Malignancy 3. Fistula 4. Those already in receipt of treatment 5. Those already on hormone replacement therapy 6. Undiagnosed vaginal bleeding 7. Oestrogen dependent tumour 8. Active thrombo-embolic disease

Design outcomes

Primary

Measure	Time frame
Clinical assessment using urinary diaries and 24 hour home pad tests.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026