Mortality and recovery of renal function in acute kidney injury patients treated with extended dialysis

Mortality and recovery of renal function in acute kidney injury patients treated with extended daily dialysis: is the duration of therapy important?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33774458

Enrollment

170

Registered

2014-04-16

Start date

2012-01-01

Completion date

Unknown

Last updated

2018-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury Urological and Genital Diseases Acute renal failure, unspecified

Interventions

The indications for dialysis are uraemic symptoms, blood urea nitrogen (BUN) level >100 mg/dl (azotaemia), volume overload, electrolyte imbalance (potassium > 6 mEq/l after clinical treatment), or aci

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 18 years of age or older 2. Patients with AKI associated with sepsis 3. Patients on an noradrenaline dose ranging from 0.3 to 0.7 ug/kg/min

Exclusion criteria

Exclusion criteria: 1. Severe chronic kidney disease (baseline creatinine higher than 4 mg/dL) 2. Previous chronic dialysis 3. Kidney transplantation 4. Noradrenaline using a dose higher than 0.7 mg/kg/min

Design outcomes

Primary

Measure	Time frame
1. During the procedures, BP monitoring is performed every 30 min. Hypotension is defined as a single systolic BP of less than 90 mm Hg or a mean arterial pressure (MAP) of less than 60 mm Hg. To treat a hypotension episode during EDD, protocols are applied involving the infusion of saline, discontinuation of UF, and an increased dose of vasoactive drugs, according to the clinical condition and fluid status of the patient. If, despite the measures above, haemodynamic instability persisted, posing risks to the patient, the therapy are discontinued. 2. Filter clotting is diagnosed as the presence of blood clots in the circuit, composed of dialyser and lines, which prevented the continuation of therapy	—

Measure

Time frame

1. During the procedures, BP monitoring is performed every 30 min. Hypotension is defined as a single systolic BP of less than 90 mm Hg or a mean arterial pressure (MAP) of less than 60 mm Hg. To treat a hypotension episode during EDD, protocols are applied involving the infusion of saline, discontinuation of UF, and an increased dose of vasoactive drugs, according to the clinical condition and fluid status of the patient. If, despite the measures above, haemodynamic instability persisted, posing risks to the patient, the therapy are discontinued. 2. Filter clotting is diagnosed as the presence of blood clots in the circuit, composed of dialyser and lines, which prevented the continuation of therapy

—

Secondary

Measure	Time frame
Hypokalaemia and hypophosphataemia are considered post-dialysis complications, characterised by serum levels below 3.5 mEq/l and 3.5 mg/dl, respectively	—

Countries

Brazil

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 23, 2026