Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?

Pre-menopausal bilateral salpingo-oophorectomy and breast cancer risk for carriers of BRCA1 and BRCA2 pathogenic variants: A pooled cohort analysis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN33767504

Enrollment

5500

Registered

2025-10-01

Start date

2025-11-30

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer Cancer

Interventions

This is an observational study that involves analysing pooled individual data that has already been collected within established cohorts. No interventions or treatments will be given and no further da

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Carrier of pathogenic or likely pathogenic variant (class 4 or 5) in BRCA1 or BRCA2 2. Born after 1920 3. Aged at least 18 years at cohort entry 4. No personal history of cancer (except cervix carcinoma in situ or non-melanoma skin cancer) at cohort entry 5. No personal history of risk-reducing bilateral mastectomy at cohort entry

Exclusion criteria

Exclusion criteria: No follow-up information available

Design outcomes

Primary

Measure	Time frame
Diagnosis of invasive breast cancer or ductal carcinoma in situ (DCIS) derived from self-report (in follow-up questionnaires), pathology reports, medical records and linkages to cancer registries at any time during follow-up.	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Australia, Austria, Canada, Czech Republic, England, France, Germany, Hungary, Netherlands, New Zealand, Norway, Poland, Spain, Sweden, United Kingdom, United States of America

Contacts

Public ContactStephanie Nesci

Stephanie.nesci@petermac.org+61 3 8559 8261

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026