Randomised controlled trial of intrathecal diamorphine in the treatment of chronic non-malignant pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33733462

Enrollment

Registered

2003-09-12

Start date

2003-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Signs and Symptoms: Pain Signs and Symptoms Pain

Interventions

1. Dose of diamorphine reduced every week by 20% of the preceding week's dose for 10 weeks 2. No change in dose of diamorphine for 10 weeks Patient is blinded to the changes made by computer telemetr

Eligibility

Inclusion criteria

Inclusion criteria: Added 07/04/10: Intrathecal pump in situ patient at Russells Hall Hospital

Exclusion criteria

Exclusion criteria: Added 07/04/10: Patients failing to give consent

Design outcomes

Primary

Measure	Time frame
1. Analgesic consumption 2. Pain level measured using Visual Analogue Score (VAS) 3. Function measured by Oswestry Disability Score (ODS) 4. Psychological parameters measured by Hospital Anxiety & Depression Score (HAD) and 5. Pain Coping Strategies Questionnaire (PCSQ) 6. Sociological parameters measured by SF-36 7. Overall assessment of change measured by Global Impression of Change (GIC)	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026