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The use of a blood protein (A-PRF) to enhance the replacement and recovery of gum tissue around tooth implants

Evaluation of apically positioned flap with A-PRF vs free gingival grafts to enhance the width of keratinized tissue around dental implants: a randomized clinical split-mouth study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN33695429
Enrollment
15
Registered
2020-08-20
Start date
2019-01-01
Completion date
Unknown
Last updated
2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Partially edentulous and requiring a replacement for missing teeth Oral Health

Interventions

Test group (Apical position flap + Advanced platelet rich fibrin) Control group (Free gingival graft) Both test and control groups were treated in the same surgical se
by a computer-generated randomization list (SPSS v23.0). The treatment methods (15 for A-PRF test group / 15 for FGGs control group).

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Older than 18 years old 2. Less than 2 mm of KT at the buccal site from the ridge crest on bilateral implants 3. Patients have a thick gingival phenotype (GT = 2 mm) 4. Adequate oral hygiene (API=1) (API= Approximal Plaque Index) and good general health

Exclusion criteria

Exclusion criteria: 1. Smokers and alcoholics (=10 cigarettes/day) 2. Patients with systemic diseases that could interfere with the healing 3. Patients undergoing bisphosphonate treatment and patients who previously received radiotherapy for the jaws 4. Patients with moderate to severe periodontitis 5. Pregnant women and breastfeeding mothers

Design outcomes

Primary

MeasureTime frame
1.Width of keratinized tissue was measured using a vacuum stent with periodontal probe from the lingual edge side of the stent to the mucogingival junction at baseline, immediately after the surgery, and 8 weeks later 2. Gingival thickness (phenotype) was measured using an acrylic stent, with an average of three measurements, at baseline, 8 weeks, and 6 months after the surgery

Secondary

MeasureTime frame
Postoperative pain was measured using a visual analog scale (VAS) from 0 (absence of pain) to 100 (most severe pain) on the day of surgery, and afterwards daily until day 6

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026