Non Invasive ventilation (NIV) in chronic ventilatory failure: A comparison of different modes of ventilation and an analysis of mechanisms of action

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33655313

Enrollment

Registered

2004-01-23

Start date

2000-01-10

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous system diseases: Other nervous system disease Nervous System Diseases

Interventions

Pressure support ventilation vs volume cycled ventilation

Eligibility

Inclusion criteria

Inclusion criteria: Patients with established chronic respiratory failure due to chest wall deformity or neuromuscular weakness stable of home nocturnal non-invasive ventilation.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Arterial blood gas tensions (pO2, PCO2)	—

Secondary

Measure	Time frame
1. Exercise tolerance (shuttle walk tests) 2. Psychometric tests 3. Central respiratory drive (using ventilatory and PO.1 response to carbon dioxide) 4. Assessment of respiratory muscle strength (sniff nasal pressures). 5. Full polysomnography (sleep quality and efficiency) 6. Health status	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026