Neuropsychological rehabilitation in patients with impairments in memory and attention after long term occupational exposure to organic solvents

Neuropsychological rehabilitation in workers with chronic solvent induced encephalopathy (CSE): a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33631515

Enrollment

Registered

2012-08-31

Start date

2002-03-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic solvent induced encephalopathy Nervous System Diseases Toxic encephalopathy

Interventions

Patient were randomised, either to: 1. Intervention (neuropsychological rehabilitation group programme consisting of: memory training improving coping skills with cognitive impairments, cognitive beha

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age > 17 years 2. Diagnosed with chronic solvent induced encephalopathy 3. 5 years or more exposure to organic solvents 4. Cessation of exposure not longer than three yrs before first diagnostic evaluation for CSE 5. Informed consent 6. Dutch speaking

Exclusion criteria

Exclusion criteria: 1. Other neurological illness 2. Alcohol or drugs related disorders 3. Psychotic symptoms 4. Radiation therapy 5. Chemotherapy 6. Previous treatment in neuropychological rehabilitation

Design outcomes

Primary

Measure	Time frame
1. Coping with cognitive impairment (CAMQ) 2. Subjectieve cognitive impairment (CFQ) 3. Meta memory (MIA) Measured pre-intervention (T0), post intervention at 3 months (T1 ) and at 7 months follow up(T2)	—

Secondary

Measure	Time frame
Health related quality of life (SF-36) measured pre-intervention (T0), post intervention at 3 months (T1) and at 7 months follow up (T2)	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026