Major Abdominal Surgery Surgery Major Abdominal Surgery
Conditions
Interventions
As of 12/03/2008 the anticipated end date of this trial was extended to 1st February 2009. The previous anticipated end date was 1st February 2008.
Infusion of dopexamine at 0.5 mcg/kg/min for 24 ho
Sponsors
York Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing scheduled resection for carcinoma of the colon, rectum, bladder, pancreas, stomach or kidney, who, after routine Cardiopulmonary exercise (CPX) testing at the Pre-assessment Clinic, have been found to have an Anaerobic Threshold (AT) less than or equal to 11.0 ml/min/m2 as measured by the V-slope method 15, or with an AT of 11.0 -14.0 ml/min/m2 and ischaemic changes on Electrocardiogram (ECG) monitoring during testing or with a significant history of ischaemic heart disease (New York Heart Association [NYHA] classification III and IV).
Exclusion criteria
Exclusion criteria: 1. Less than 60 years of age unless they have significant co-morbidities (American Society of Anaesthesiologists (ASA) score three or greater) 2. Having emergency or vascular procedures 3. ASA grade five 4. Refuse or are unable to give informed consent 5. Hypertrophic Obstructive Cardiomyopathy, aortic stenosis, phaeochromocytoma, a low platelet count, or have used a monoamine oxidase inhibitor within the last 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morbidity at five, ten, and 15 days using the Post-Operative Morbidity Score (POMS) score. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of stay in hospital after surgery 2. Recovery parameters (drinking, eating, mobilising) 3. Incidence of post-operative complications 4. Peri-operative haemodynamic variables (heart rate, blood pressure, Central Venous Pressure [CVP]) 5. Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) score for surgical risk assessment 6. Oxygen delivery | — |
Countries
United Kingdom
Outcome results
None listed