Severe and very severe pneumonia defined clinically Respiratory Pneumonia
Conditions
Interventions
Interventions amended as of 17/09/2007:
Zinc sulphate or placebo. Zinc will be given once daily orally at a dose of 10 mg in those aged 2-11 months and 20 mg in those 12-59 months. All participants
zinc sulphate has been used throughout the trial.
Interventions provided at time of registration:
Zinc acetate or placebo. Zinc will be given once daily orally at a dose of 10 mg in those aged 2-11
Sponsors
Medical Research Council (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Prior to 18/10/10: Children aged 2-59 months presenting with severe or very severe pneumonia to the MRC Hospital or the Royal Victoria Teaching Hospital, Banjul. Modified on 18/10/10: 'Children aged 2-59 months presenting with severe or very severe pneumonia to the MRC Hospital, the Royal Victoria Teaching Hospital, Banjul, and the health centres at Fajikunda, Brikama, Serekunda and Basse.
Exclusion criteria
Exclusion criteria: Children with severe malnutrition or signs of systemic infection other than pneumonia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment failure at 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| The following will be assessed after 6 months supplementation of zinc or placebo in a subgroup: 1. Time to resolution of signs of severe and very severe pneumonia 2. Length of admission 3. Height 4. Multi-antigen skin testing | — |
Countries
Gambia
Outcome results
None listed