Injury, Occupational Diseases, Poisoning: Radiation injuries Injury, Occupational Diseases, Poisoning Radiation injuries
Conditions
Interventions
Patients will be randomised in a 2 x 2 factorial fashion to:
1. Pentoxifylline (trental)
2. High dose vitamins
3. Pentoxifylline (trental) with high dose vitamins
4. Placebo
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients referred at least three months after pelvic radiotherapy 2. Patients must have gastrointestinal symptoms which were not present before radiotherapy 3. Must have undergone adequate gastroenterological assessment to reach a diagnosis 4. Must have residual gastrointestinal symptoms after three months of best therapy
Exclusion criteria
Exclusion criteria: 1. Previous cerebrovascular haemorrhage 2. Previous retinal haemorrhage 3. Liver cirrhosis 4. Symptomatic coronary artery disease 5. Abnormal renal function and creatine clearance 6. History of renal tract stone 7. Evidence of recurrent disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Changes in the bowel toxicity scale Inflammatory Bowel Disease Questionnaire (IBDQ) 2. Changes in the Vaizey incontinence questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed