Long-term effects of strontium ranelate on knee osteoarthritis symptoms: a two year prospective, randomised, placebo-controlled study

Long-term effects of strontium ranelate on knee osteoarthritis symptoms. A 2-year prospective, randomised, placebo-controlled study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN33207390

Enrollment

140

Registered

2006-10-12

Start date

2006-11-30

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis Musculoskeletal Diseases Arthrosis

Interventions

Strontium ranelate versus placebo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Caucasian males or females 2. Aged 45 years or over 3. Primary knee osteoarthritis 4. Under an effective contraceptive method for non-menopausal women

Exclusion criteria

Exclusion criteria: 1. Knee prosthesis already implanted, or foreseen to be implanted 2. Hip prosthesis already implanted or not well-tolerated or foreseen to be implanted 3. Previous osteotomy on the inferior limbs

Design outcomes

Primary

Measure	Time frame
Changes in the algofunctional behaviour of the target knee.	—

Secondary

Measure	Time frame
1. Algofunctional assessment 2. Radiographic assessment of knee osteoarthritis 3. Physical examination	—

Countries

Belgium

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026