Topic: Cardiovascular
Conditions
Interventions
RIPC, Remote Ischaemic Pre-conditioning (RIPC) will be comprised of four 5 min cycles of right upper limb ischaemia, induced by a blood pressure cuff inflated to 200 mm Hg, with an intervening 5 min o
Sponsors
Imperial College London (UK)
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 03/11/2014: 1. Age =18 2. Patients undergoing elective (or urgent) first-time CABG or AVR Previous inclusion criteria: 1. Male and female, age >=40 and <85 years 2. Patients undergoing elective (or urgent) first-time CABG or AVR
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 03/11/2014: 1. Cardiogenic shock or cardiac arrest, 2. Significant peripheral arterial disease affecting upper limbs, 3. Renal failure (with a GFR 20 mmol/L, Prothrombin > 2.0 ratio) 4. Pulmonary disease (FEV1 < 40% predicted) 5. Renal failure (with a GFR < 30 ml/min/1.73m2) 6. Glibenclamide or nicorandil (as these medications may interfere with RIPC) 7. Participation in another interventional study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial Injury; Timepoint(s): 2 pre-operatively and 6, 12, 24, 48 and 72 hours after end of cardioplegic arrest | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical endpoints measured from admission up till 3 months post-operatively 2. Inflammatory and oxidative stress measured two pre-operatively and 5 postoperatively at 6, 12, 24, 48 & 72 hours after end of cardioplegic arrest | — |
Countries
England, United Kingdom
Outcome results
None listed