Sarcopenia Musculoskeletal Diseases
Conditions
Interventions
Interventions will consist of resistance training programs combined with essential amino acid (leucine) supplementation or non-essential amino acid (alanine) supplementation for 10 weeks, pre-surgery.
Sponsors
Barts and the London School of Medicine (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Elderly patients (60+ years), males and females, awaiting elective total hip arthroplasty but otherwise in relatively good health 2. Participants must have a good understanding of English to understand verbal explanations and written information given in English 3. Participants must be able to give fully informed consent
Exclusion criteria
Exclusion criteria: All participants will be screened by a physician and will be excluded from the study if they suffer from or have ever suffered from: 1. Previous stroke 2. Uncontrolled cardiovascular disease 3. Motor neurone disease 4. Parkinson's disease 5. Medically diagnosed osteoporosis 6. Type II diabetes 7. Hypertension or myocardial infarction within the previous 2 years 8. Acute febrile or systemic disease within the past 2 years 9. Currently taking beta blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Muscle thickness and architecture, measured by ultrasound 2. Muscle strength, measured by dynamometer These outcomes will be assessed at baseline (10 weeks prior to surgery), immediately prior to surgery, and at 1 and 3 months post surgery. | — |
Countries
United Kingdom
Outcome results
None listed