The effect of ephedrine and phenylephrine on the ED50 of intrathecal bupivacaine required to provide anaesthesia for Caesarean section

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN32635781

Enrollment

Registered

2006-09-29

Start date

2006-02-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth: Anaesthesia Pregnancy and Childbirth Single delivery by caesarean section

Interventions

Patients were randomised to receive 1. either phenylephrine at a rate of 16.6 µg min^?1 (concentration 1µg ml^?1) or ephedrine at a rate of 1.5 mg min^?1 (concentration 90 µg ml^?1) 2. varying doses o

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients undergoing elective CS with a viable singleton foetus who require regional anaesthesia will be identified.

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

Measure	Time frame
The ED50 of intrathecal heavy bupivacaine with 25mcg fentanyl required to achieve a block to touch to Xiphisternum in the ephedrine and phenylephrine groups.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026