Haemodialysis catheter related sepsis Infections and Infestations Complications following infusion, transfusion and therapeutic injection
Conditions
Interventions
Control group will receive usual heparin line locks between dialysis sessions.
Intervention group will receive a line lock containing heparin, vancomycin and gentamicin.
Sponsors
Wirral Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients requiring insertion of a tunnelled haemodialysis catheter (THDC) for haemodialysis.
Exclusion criteria
Exclusion criteria: 1. Patients on prolonged courses of antibiotics (oral or parenteral) i.e. for greater than 2 weeks. (This may reduce the incidence of CRI and therefore confound the results). 2. Patients with a known allergy to vancomycin or gentamicin 3. Patients known to suffer from heparin induced thrombocytopenia 4. Patients who are pregnant or plan to become pregnant. (Vancomycin and gentamicin are potentially toxic to the fetus). 5. An inability to provide informed consent to participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time in days from insertion of tunnelled haemodialysis catheter (THDC) to first catheter related infection (CRI). CRI will be diagnosed by a combination of clinical suspicion, raised temperature, blood tests (white cell count and inflammatory markers) and the results of blood cultures from the tunnelled haemodialysis catheter (THDC) and from a peripheral vein. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mean haemoglobin concentration 2. Mean erythropoietin dose adjusted for body mass 3. Mean serum albumin concentration 4. Mean number of days in hospital per annum 5. Mean number of hospital admissions per annum | — |
Countries
United Kingdom
Outcome results
None listed